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Environmental and health effects of the herbicide glyphosate

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Environmental and health effects of the herbicide glyphosate

In: The Science of the total environment, 2018, Vol.616-617, p.255-268
Autor: Van Bruggen, A.H.C , He, M.M , Shin, K , Mai, V , Jeong, K.C , Finckh, M.R , Morris, J.G
Ort, Verlag, Jahr: Netherlands, Elsevier B.V, 2018
ISBN/ISSN/ISMN: 0048-9697
Kollektion: Medline
Erscheinungsform: article

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Autor:Van Bruggen, A.H.C
Autor:He, M.M
Autor:Shin, K
Autor:Mai, V
Autor:Jeong, K.C
Autor:Finckh, M.R
Autor:Morris, J.G
Titel:Environmental and health effects of the herbicide glyphosate
Verlag:Elsevier B.V
Zusammenfassung:The herbicide glyphosate, N-(phosphonomethyl) glycine, has been used extensively in the past 40years, under the assumption that side effects were minimal. However, in recent years, concerns have increased worldwide about the potential wide ranging direct and indirect health effects of the large scale use of glyphosate. In 2015, the World Health Organization reclassified glyphosate as probably carcinogenic to humans. A detailed overview is given of the scientific literature on the movement and residues of glyphosate and its breakdown product aminomethyl phosphonic acid (AMPA) in soil and water, their toxicity to macro- and microorganisms, their effects on microbial compositions and potential indirect effects on plant, animal and human health. Although the acute toxic effects of glyphosate and AMPA on mammals are low, there are animal data raising the possibility of health effects associated with chronic, ultra-low doses related to accumulation of these compounds in the environment. Intensive glyphosate use has led to the selection of glyphosate-resistant weeds and microorganisms. Shifts in microbial compositions due to selective pressure by glyphosate may have contributed to the proliferation of plant and animal pathogens. Research on a link between glyphosate and antibiotic resistance is still scarce but we hypothesize that the selection pressure for glyphosate-resistance in bacteria could lead to shifts in microbiome composition and increases in antibiotic resistance to clinically important antimicrobial agents. We recommend interdisciplinary research on the associations between low level chronic glyphosate exposure, distortions in microbial communities, expansion of antibiotic resistance and the emergence of animal, human and plant diseases. Independent research is needed to revisit the tolerance thresholds for glyphosate residues in water, food and animal feed taking all possible health risks into account.Sources:Antibiotic resistance papers: Cantas et al., 2013Glyphosate use (relative area sprayed): USDA NASS, 2014. [Display omitted]•Glyphosate and its degradation product AMPA have accumulated in the environment.•Chronic low dose effects on animals and humans have been documented recently.•Shifts in microbial community composition in soil, plants and animal guts resulted.•Glyphosate and antibiotic resistance have arisen in fungi and bacteria in parallel.•Glyphosate may serve as one of the drivers for antibiotic resistance.
Kollektion:MEDLINE (Ovid)
Kollektion:Academic OneFile (A&I only)
In:The Science of the total environment, 2018, Vol.616-617, p.255-268
Primo Volltext:no_fulltext